PDRN: the viral skincare ingredient derived from salmon sperm

In the world of skincare, you’ve probably come across this ingredient. PDRN went viral due to its unconventional source: salmon sperm. Beyond being a favourite in some celebrity facial treatments, like those of Kim Kardashian, the medical terminology surrounding it has left many with more questions than answers.

So, what exactly is it? PDRN, or polydeoxyribonucleotide, does not always come from fish. Today, there are three versions: marine, extracted from salmon or other fish; plant-based, suitable for vegans; and microbial, created in the laboratory.

Interestingly, although the idea of salmon sperm may sound unusual, dermatologists support its use. PDRN helps stimulate collagen, accelerate cell regeneration, and improve skin elasticity. Dermatologist Dr Jae Yong Ban notes that PDRN helps rebuild skin proteins, favouring regeneration, which is why it is used in both treatments and daily products.

Moreover, it is perfect for combating signs of ageing. Skin becomes more sensitive with age, and according to studies, almost 70% of people in their thirties experience some form of sensitivity. This means the skin barrier is weakened and regeneration becomes necessary.

PDRN is not a recent trend. In Korea, it has been used in dermatology for over a decade, with proven efficacy and safety. Today, it is a common ingredient in clinics, both for professional treatments and products for home use.

So, if you are concerned about the origin of salmon or other fish, you can opt for the plant-based or lab-made versions of PDRN and still benefit from its properties. TikTok may have given it a bad reputation, but dermatologists agree that it is safe and effective, both at home and in the clinic.